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MIF was proven to rescue neurons from oxidative pressure induced read more apoptosis by inhibiting caspase-3 activation, and MIF-knockout mice also experienced additional dead neurons, as well as a increased infarct measurement following induction of an experimental stroke [124]. Neurodegenerative Conditions, which includes Parkinson’s ailment (
MIF is needed to the interaction between NLRP3 and also the intermediate filament protein vimentin, that's important for NLRP3 activation. more, we display that MIF interacts with NLRP3, indicating a role for MIF in inflammasome activation impartial of its role to be a cytokine. These details progress our knowledge of how MIF regulates inflammation